The role of alpha blockers in the treatment of prostate adenoma

The role of alpha blockers in the treatment of prostate adenoma

In patients with moderate enlargement of the prostate and urinary tract symptoms of moderate intensity but nevertheless sufficiently embarrassed to claim that treatment, alpha blockers are often prescribed as first line.

Alpha blocker is short for antagonist of alpha-adrenergic receptors, a class of drugs was initially developed for the treatment of hypertension.

Alpha blockers allow the relaxation of the smooth muscle in blocking the receptors that receive chemical signals leading to contraction this fiber. In the prostate, the relaxation of the smooth muscle component of the gland decreases the voltage of encirclement by the gland of the urethra, allowing the urine to flow more freely.

Alpha blockers categories: selective and non-selective.

Because non-selective blockers alpha – Doxazosin (Zoxan), prazosin (Minipress) and Terazosin (Hytrin) – are likely to lower blood pressure, it is not the best choice for patients who are already taking antihypertensive treatment . The combination of several anti-hypertensive drugs may cause hypotensive jolts cause fatigue or discomfort in patients, especially the position changes such as rising from a chair or bed (orthostatic hypotension).

Brutal hypotensive episodes can be dangerous in men who have vascular disease, putting them at high risk of cardiovascular accident.

Conversely selective alpha blockers (Alfuzosin, Silodosin and Tamsulosin) have no effects on blood pressure balance, which makes them attractive for men who can not bear a reduction in pressure figures blood.

Other side effects of alpha blockers are swelling (edema) of the ankles and retrograde ejaculation, which is the ejection of semen backward into the bladder during orgasm rather than in the natural sense, forward toward the channel of the urethra and the outside.

Some alpha blockers also resound on the volume of ejaculate. One study showed that Tamsulosin reduced volume of ejaculate while Alfuzosin has no effect on the volume ejaculated.

The difference between alpha blockers is mainly in relation to their adverse effects. Although there is little data to direct comparisons, the various alpha blockers seem equally effective compared to the other to treat prostatic hyperplasia (BPH, also called benign prostatic hyperplasia) and mictionelle discomfort that it causes. In addition, side effects vary more from one patient to the other that of a molecule to another, and it can be several successive prescriptions in the same patient before finding the right alpha blocker for that patient .