The journal is called “Small” because she is interested in the infinitely small. This Karlsruhe scientific team of Institute of Technology (KIT) have developed a 3D model based on cryogels reproducing the natural processes of development and progression of prostate cancer. The model can track the progress of each cancer cell. Already recognized by experts as a major research platform of this cancer by far the most common in men, this 3D model can remove an obstacle which basic research has always faced: follow the progression of the disease from the onset of metastasis, and understand the interaction of cancer cells with their environment.
Since October 2012, the team led by Dr. Friederike J. Gruhl working on this model of the prostate in 3D and is able to develop a truly “biomimetic” system or a cell culture model to track the progression of cancer human prostate in vitro. Its base material, which consist of synthetic polymers which cryogels can be assembled to form three-dimensional porous structures whose mechanical properties are very close to those of the natural tissue. The pores are obtained by water bubbles trapped and frozen.
Research shows that this model is a stable cell culture system, similar to a 3D fabric, in which the specific gene expression for prostate cancer is not only possible but can even be enhanced compared to conventional 2D models . The researchers demonstrated this by cultivating model of cancer cells to androgen-sensitive prostate (LNCaP). They envisage, in the near future, grow healthy cells of the prostate tissue and cancer cells to test the efficacy and safety of new molecules against prostate cancer.
Source: Superporous Poly (ethylene glycol) diacrylate Cryogel with a Defined Elastic Modulus for Prostate Cancer Cell Research (https://www.santelog.com/news/cancerologie/cancer-de-la-prostate-un-modele-en-cryogels-pour-suivre-les-cellules-cancereuses-a-la-trace_15940_lirelasuite.htm)
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