Accueil » Prostate cancer » The diagnostic » What is a prostate biopsy? Dec 04 2008 0 What is a prostate biopsy? The operation today is carried out under local anaesthetic so it should be totally painless. It lasts about 15 minutes and no stay in hospital is necessary. The discomfort is usually moderate. Antibiotic treatment is given for five days after the biopsy to limit risks of infection.